Familial myelodysplasia.
نویسندگان
چکیده
منابع مشابه
Familial myelodysplasia and acute myeloid leukaemia--a review.
Familial occurrence of myelodysplasia (MDS) and/or acute myeloid leukaemia (AML) is rare but can provide a useful resource for the investigation of predisposing mutations in these myeloid malignancies. To date, examination of families with MDS/AML has lead to the detection of two culprit genes, RUNX1 and CEBPA. Germline mutations in RUNX1 result in familial platelet disorder with propensity to ...
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Cutaneous manifestations of haematological malignancies, although well recognized in acute monoblastic leukaemia and lymphoma, are relatively uncommon in primary myelodysplastic syndrome (MDS), which is a group of heterogeneous disorders formerly known as pre-leukaemia. Previously reported cases of skin involvement in this syndrome have been confined to a sub-type of MDS, namely chronic myelomo...
متن کاملImmunophenotyping of myelodysplasia.
Cell maturation anomalies in bone marrow samples have long been recognized by the patient scrutiny of morphologists, have led to detailed descriptions of possible abnormalities and later to clinically relevant classifications of myelodysplasia (MDS). That the diagnosis and fine description of MDS belong to the realm of morphologists has long been considered a prerogative although, since the ear...
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The manifestations of HIV infection are known to involve every organ system and aspect of pathophysiology. The bone marrow is particularly susceptible to the ravages of HIV infection; in addition to non-Hodgkin lymphoma, myelodysplasia and acute leukemia have been associated with HIV infection, although they are not considered to be AIDS-defining illnesses.1-5 Here we report the case of a 58-ye...
متن کاملMyelodysplasia in Childhood
Myelodysplasia is a heterogenous group of disorders that was earlier described as preleukemia, refractory anemia with excess of blasts, subacute myeloid leukemia, oligoleukemia and odoleukemia . This disorder is predominantly a ineffective marrow due to a stem cell disorder characterized by progressive cytopenia(s), associated with a hypercellular, normocelular or hypocellular marrow and associ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1989
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.299.6698.551